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Genetic ablation of the Bsx homeodomain transcription factor in zebrafish: Impact on maturepineal gland morphology and circadian behaviorLO

GO汇报人：刘炜Authors:Mikkel Bloss Carstensen1,2, Adar Medvetzky2, Alon Weinberger2, Wolfgang Driever3, YoavGothilf2,4, and Martin Fredensborg Rath1IF:13中科院1区 TOP期刊01IntroductionPART ONEPART ONEPineal gland1.The pineal gland is a neuroendoc.001pp.coman responsible for production of the noc-turnal hormone melatonin.

2.The mammalian pineal gland secretes the nocturnal hormone melatonin, which is synthesized from tryptophan by the ac-tion of the pineal enzymes tryptophan hydroxylase 1 (TPH1), arylalkylamine N-acetyltransferase (AANAT), and acetylse-rotonin O-methyltransferase (ASMT).

3.The mammalian pineal gland secretes the nocturnal hormone melatonin, which is synthesized from tryptophan by the ac-tion of the pineal enzymes tryptophan hydroxylase 1 (TPH1), arylalkylamine N-acetyltransferase (AANAT), and acetylse-rotonin O-methyltransferase (ASMT).

PART ONEBsx1. A specific set of homeobox gene-encoded transcription factors govern pineal development, and some are expressed in adulthood. The brain-specific homeobox gene (Bsx) falls into both categories.

2. The brain-specific homeobox gene (Bsx) is expressed in the developing pineal gland at early stages and is essential for proper pineal morphogenesis in mice, frogs (Xenopus) and zebrafish.

3 内容过长，仅展示头部和尾部部分文字预览，全文请查看图片预览。 sympathetic adrenergic input to the gland. The effects of siRNA-mediated Bsx knockdown on expression of genes encoding melatonin-synthesizing enzymes and homeodomain proteins in cultured pineal cells.RNA sequencing identifies Bsx as a regulator of the adult rat pineal transcriptome[文章尾部最后300字内容到此结束,中间部分内容请查看底下的图片预览]

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