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Genetic ablation of the Bsx homeodomain transcription factor in zebrafish: Impact on maturepineal gland morphology and circadian behaviorLO

GO汇报人：刘炜Authors:Mikkel Bloss Carstensen1,2, Adar Medvetzky2, Alon Weinberger2, Wolfgang Driever3, YoavGothilf2,4, and Martin Fredensborg Rath1IF:13中科院1区 TOP期刊01IntroductionPART ONEPART ONEPineal gland1.The pineal gland is a neuroendoc.001pp.coman responsible for production of the noc-turnal hormone melatonin.

2.The mammalian pineal gland secretes the nocturnal hormone melatonin, which is synthesized from tryptophan by the ac-tion of the pineal enzymes tryptophan hydroxylase 1 (TPH1), arylalkylamine N-acetyltransferase (AANAT), and acetylse-rotonin O-methyltransferase (ASMT).

3.The mammalian pineal gland secretes the nocturnal hormone melatonin, which is synthesized from tryptophan by the ac-tion of the pineal enzymes tryptophan hydroxylase 1 (TPH1), arylalkylamine N-acetyltransferase (AANAT), and acetylse-rotonin O-methyltransferase (ASMT).

PART ONEBsx1. A specific set of homeobox gene-encoded transcription factors govern pineal development, and some are expressed in adulthood. The brain-specific homeobox gene (Bsx) falls into both catego 内容过长，仅展示头部和尾部部分文字预览，全文请查看图片预览。 skull or a cavity,suggesting the total absence of the pineal gland as a result of bsx loss-of-function .The pineal gland structure is not detected by histology in adult bsx-/- mutant zebrafish S-antigen (Sag), a phototransduction protein found in pineal and retinal photoreceptors. In the brain, a strong pineal-specific signal was detected in wildtype (bsx+/+) and heterozygote (bsx+/-) fish , while a signal above background level was not detected in bsx-/- mutants .Pineal gland transcripts show drastically reduced levels in adult bsx-/- mutant zebrafishRhythmic behavior is disrupted in bsx-/- mutant zebrafish larvaeBsx is expressed in the developing rat pineal gland into adulthoodRhythmic behavior is disrupted in bsx-/- mutant zebrafish larvaeTissue-specific expression of Bsx in the adult rat and human pineal gland. Rhythmic expression of Bsx in the adult rat pineal gland.Regulation of pineal Bsx expression by the sympathetic adrenergic input to the gland. The effects of siRNA-mediated Bsx knockdown on expression of genes encoding melatonin-synthesizing enzymes and homeodomain proteins in cultured pineal cells.RNA sequencing identifies Bsx as a regulator of the adult rat pineal transcriptome[文章尾部最后300字内容到此结束,中间部分内容请查看底下的图片预览]

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