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Carmeda? and Trillium? BiosurfacesCompetition

MEDTRONIC CONFIDENTIALBiocompatible surfaces for CPBAvailable in various geographiesCoatings with heparin:

Carmeda? Bioactive Surface (Medtronic)

Trillium? Biosurface (Medtronic)

Bioline? (Maquet)

GBS? (Gish)

Coatings without heparin

Xcoating? (Terumo)

Ph.I.S.I.O (Dideco/Sorin/COBE)

Softline (Maquet)

GBS without heparin (Gish)

Surface modification without heparin

SMARxT? (Cobe)

Safeline? (Maquet)MEDTRONIC CONFIDENTIALUse “correct” biosurface terminology“Heparin Biosurface” – Correct

“Coating WITHOUT Heparin” – Correct

Non-Heparin Coating – Incorrect!

These coatings are MISSING the benefits of heparin!

DO NOT use “Non-Heparin” terminology that positions these coatings in a novel category

Make sure your customers understand that these coatings LACK heparin’s benefits.MEDTRONIC CONFIDENTIALCompetition(see coatings competitive matrix book)MEDTRONIC CONFIDENTIALCompetition(see coatings competitive matrix book)Xcoating?TerumoMEDTRONIC CONFIDENTIALXcoating?TerumoXcoating is composed of an amphiphilic polymer:

Hydrophobic where it contacts the device

Hydrophilic at the blood contact surface

Proteins do not denature

Therefore, platelets will not adhere to surfaceMEDTRONIC CONFIDENTIALUedaira H, Hyoumen, 13, 302, 1975Hazlewood CF, Nicols BL, Chamberlain NF, Nature, 222,747, 1969

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