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A coordinated Global Research Roadmap to respond to theD-19 epidemic and beyond There is broad consensus on the need for research to focus on actions that can save lives now and to facilitate action so that those affected are promptly diagnosed and receive optimal care; while integrating innovation fully within each research area. Moreover, there is an imperative to support research priorities in a way that leads to the development of sustainable global research platforms pre-prepared for the next disease X epidemic; thus, allowing for accelerated research, innovative solutions and R&D of diagnostics, therapeutics and vaccines, as well as their timely and equitable access for those at highest risk. 4 March 2020 2019 novel Coronavirus Global research and innovation forum: towards a research roadmap Table of contents Table of contents _____________________________________________________________________ 2 ABOUT THIS DOCUMENT _______________________________________________________________ 7 GOALS OF THE GLOBAL RESEARCH ROADMAP __________________________________________ 9 PROPOSED STRATEGIC APPROACHES AND CRITICAL ACTIONS___________________________ 11 IMMEDIATE NEXT STEPS TO CONTRIBUTE TO CONTROL THE OUTBREAK_____________________ 13 SELECTED KNOWLEDGE GAPS _________________________________________________________ 14 CROSS-CUTTING RESEARCH PRIORITIES ________________________________________________ 15 SCALING UP RESEARCH AND INNOVATION ACTIONS ___________________________________ 16 TIMELINE FOR IMPLEMENTATION OF SELECTED RESEARCH ACTIONS ______________________ 17 MIDTERM AND LONGTERM PRIORITIES TO CONTRIBUTE TO CONTROL THE OUTBREAK _______ 23 1. Virus natural history, transmission and diagnostics ______________________________________ 23 2. Animal and environmental research on the virus origin, and management measures at the human-animal interface __________________________________________________________________ 23 3. Epidemiological studies _______________________________________________________________ 24 4. Clinical management _________________________________________________________________ 24 5. Infection prevention and control, including health care workers’ protection ______________ 25 6. Candidate therapeutics R&D __________________________________________________________ 25 7. Candidate vaccines R&D______________________________________________________________ 25 8. Ethics Considerations for Research _____________________________________________________ 26 9. Social Sciences in the Outbreak Response _____________________________________________ 26 OPTIMIZNG FUNDING EFFORTS ________________________________________________________ 27 GOVERNANCE ______________________________________________________________________ 28 VIRUS NATURAL HISTORY, TRANSMISSION AND DIAGNOSTICS ___________________________ 31 State of the Art ____________________________________________________________________________ 31 Knowledge gaps _________________________________________________________________________ 31 Clinical virus detection ___________________________________________________________________________ 31 Immunity and immune diagnostics ________________________________________________________________ 32 Tools for infection control _________________________________________________________________________ 32 Engineered solutions to clinical diagnostics ________________________________________________________ 32 Ongoing research efforts __________________________________________________________________ 32 2 2019 novel Coronavirus Global research and innovation forum: towards a research roadmap Research priorities ________________________________________________________________________ 33 Other research priorities __________________________________________________________________________ 34 What are the key milestones per research priority? _________________________________________ 34 ANIMAL AND ENVIRONMENTAL RESEARCH ON THE VIRUS ORIGIN, AND MANAGEMENT MEASURES AT THE HUMAN-ANIMAL INTERFACE _________________________________________ 36 State of the art ____________________________________________________________________________ 36 Knowledge gaps _________________________________________________________________________ 37 Ongoing research efforts __________________________________________________________________ 37 Research priorities ________________________________________________________________________ 38 What are the key milestones per research priority___________________________________________ 40 Essential references _______________________________________________________________________ 41 EPIDEMIOLOGICAL STUDIES ___________________________________________________________ 42 State of the Art ____________________________________________________________________________ 42 Key epidemiological parameters __________________________________________________________ 42 Transmission dynamics ____________________________________________________________________ 42 Disease severity __________________________________________________________________________ 43 Susceptibility _____________________________________________________________________________ 43 Control and mitigation measures __________________________________________________________ 44 Knowledge gaps _________________________________________________________________________ 45 Transmission dynamics ___________________________________________________________________________ 45 Severity _________________________________________________________________________________________ 45 Susceptibility ____________________________________________________________________________________ 45 Control and mitigation measures _________________________________________________________________ 45 Ongoing research efforts __________________________________________________________________ 46 Research priorities ________________________________________________________________________ 47 What are the key milestones per research priority___________________________________________ 49 Essential references _______________________________________________________________________ 50 CLINICAL CHARACTERIZATION AND MANAGEMENT ____________________________________ 51 State of the art ____________________________________________________________________________ 51 Knowledge gaps _________________________________________________________________________ 51 Scientific gaps ___________________________________________________________________________________ 51 Operational gaps ________________________________________________________________________________ 52 Ongoing research efforts __________________________________________________________________ 52 3 2019 novel Coronavirus Global research and innovation forum: towards a research roadmap Research priorities ________________________________________________________________________ 53 Objective 1: Define the natural history of COVID-19 infection _______________________________________ 53 Objective 2: Determine interventions that improve the clinical outcome of COVID-19 infected patients53 Objective 3: Determine optimal clinical practice strategies to improve the processes of care_________ 53 Objective 4: Determine how best to link key research questions with researchers in affected regions who are able to recruit patients _______________________________________________________________________ 54 Objective 5: Develop platform(s) to doc.001pp.commonality of data collection across trials, and collaborations between trials _____________________________________________________________________ 54 What are the research priorities for clinical research for this outbreak and beyond?___________ 55 What are the key milestones per research priority___________________________________________ 57 Essential references _______________________________________________________________________ 59 INFECTION PREVENTION AND CON 内容过长，仅展示头部和尾部部分文字预览，全文请查看图片预览。 al Guidelines for Health-related Research Involving Humans. 2016, CIOMS publications: Geneva. 28. World Health Organisation, Guidance for Managing Ethical Issues in Infectious Disease Outbreaks. 2016, WHO: Geneva, Switzerland. 29. Greenhalgh, T., et al., Frameworks for supporting patient and public involvement in research: Systematic review and co-design pilot. Health Expectations, 2019. 22(4): p. 785-801. 30. WHO, Health Emergency and Disaster Risk Management Framework. 2019, WHO: Geneva. 96 [文章尾部最后500字内容到此结束,中间部分内容请查看底下的图片预览]请点击下方选择您需要的文档下载。

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